Cushing syndrome due to adrenal tumor is a form of
Other forms of Cushing syndrome include:
Cushing disease Ectopic Cushing syndrome Exogenous Cushing syndrome
Adrenal tumor – Cushing syndrome
Adrenal tumors are rare. They can be noncancerous (benign) or cancerous (malignant).
Noncancerous tumors that can cause Cushing syndrome include:
- Adrenal adenomas
Cancerous tumors that may cause Cushing syndrome include an
Most people with Cushing syndrome have:
- Round, red, full face (
- Slow growth rate in children
- Weight gain with fat accumulation on the trunk, but fat loss from the arms, legs, and buttocks (central obesity)
Skin changes that are often seen:
- Skin infections
- Purple marks (1/2 inch or more wide), called striae, on the skin of the abdomen, thighs, and breasts
- Thin skin with easy bruising
Muscle and bone changes include:
- Backache, which occurs with routine activities
Bone pain or tenderness
- Collection of fat between the shoulders and above the collar bone
- Rib and spine fractures caused by thinning of the bones
- Weak muscles, especially of the hips and shoulders
Women often have:
- Excess hair growth on the face, neck, chest, abdomen, and thighs
- Periods that become irregular or stop
Men may have:
- Decreased or no desire for sex
Other symptoms that may occur include:
Mental changes, such as depression, anxiety, or changes in behavior Fatigue
- Increased thirst and urination
Exams and Tests
The health care provider will perform a physical exam and ask about your symptoms.
Tests to confirm Cushing syndrome:
24-hour urine sampleto measure cortisoland creatininelevels
- Blood tests to check ACTH, cortisol, and potassium levels
Dexamethasone suppression test Blood cortisol levels
- Blood DHEA level
- Saliva cortisol level
Tests to determine cause or complications include:
- Bone mineral density
- Fasting glucose
Surgery is done to remove the adrenal tumor. Often, the entire adrenal gland is removed.
Glucocorticoid replacement treatment is usually needed until the other adrenal gland recovers from surgery. You may need this treatment for 9 to 12 months.
If surgery is not possible, such as in cases of adrenal cancer, medicines can be used to stop the release of cortisol.
Patients with an adrenal tumor who have surgery have an excellent outlook. For adrenal cancer, surgery is sometimes not possible. When surgery is performed, it does not always cure the cancer.
Cancerous adrenal tumors can spread to the liver or lungs.
When to Contact a Medical Professional
Call your health care provider if you develop any symptoms of Cushing syndrome.
Appropriate treatment of adrenal tumors may reduce the risk of complications in some patients with tumor-related Cushing syndrome.