Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. The tubules normally allow water to be removed from the kidney and returned into the blood, without leaking into the urine.
Causes, incidence, and risk factors
Nephrogenic diabetes insipidus (NDI) occurs when the kidney tubules do not respond to a chemical in the body called antidiuretic hormone (
As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine. This makes you produce large amounts of urine.
NDI is rare. Congenital diabetes insipidus is present at birth as a result of defect passed down through families that usually affects men. However, women can pass the gene on to their children.
Most commonly, NDI develops because of other reasons. This is called an acquired disorder. Factors that can trigger the acquired form of this condition include:
Blockage in the urinary tract
High calcium levels
Low potassium levels
Use of certain drugs (lithium, demeclocycline, amphotericin B)
You may have intense or uncontrollable thirst, and crave ice water. You will produce large amounts of urine, usually more than 3 – 15 liters per day.
If you do not drink enough fluids, dehydration can result. Symptoms may include:
- Dry mucous membranes
- Dry skin
- Sunken appearance to eyes
- Sunken fontanelles (soft spot) in infants
Other symptoms that can occur due to inadequate fluids include:
- Low body temperature
- Muscle pains
Rapid heart rate
- Weight loss
Signs and tests
A physical exam may reveal:
Low blood pressure
Signs of dehydration
Testing may reveal:
- High serum
- High urine output, regardless of how many fluids you drink
- Kidneys don’t concentrate urine when the person is given ADH
- Normal or high ADH levels
Other tests that may be done include:
Serum sodium Urine 24 hour volume Urine concentration test Urine specific gravity
The goal of treatment is to control the body’s fluid levels. Patients will be given a large amount of fluids. The amount of fluids given should be about equal to the amount of urine produced.
If the condition is due to a certain medication, stopping the medicine may improve symptoms. Never stop taking any medication without first talking to your doctor.
A medicine called hydrochlorothiazide may improve symptoms. This may be used alone or in combination with other medications, including amiloride or indomethacin. Although hydrochlorothiazide is a diuretic (these medications are usually used to increase urine output), in certain cases it can actually reduce urine output for people with NDI .
If a person drinks enough fluids, this condition has no significant effects on the fluid or
If the person does not drink enough fluids,
NDI that is present at birth is a long-term condition requiring lifelong treatment.
- Dilation of the ureters and bladder
- High blood sodium (
- Severe dehydration
Calling your health care provider
Call your health care provider if you have symptoms of this disorder.
There is no known way to prevent congenital nephrogenic diabetes insipidus.
Treating the disorders that can lead to the acquired form of the condition may prevent it from developing in some cases. Medications should only be used under the supervision of the health care provider.