Goodpasture syndrome is a rare disease that can involve
Some forms of the disease involve just the lung or the kidney, but not both.
Anti-glomerular basement membrane antibody disease; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis – pulmonary hemorrhage
Goodpasture syndrome is an
These substances are called anti-glomerular basement membrane antibodies. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane antibodies are
Sometimes this disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.
The immune system’s faulty response causes bleeding in the air sacs of the lungs and inflammation in the kidney’s filtering units.
Men are eight times more likely to be affected than women. The disease most commonly occurs in early adulthood.
Symptoms may occur very slowly over months or even years, but they often develop very quickly over days to weeks.
Loss of appetite, fatigue, and
Lung symptoms may include:
- Coughing up blood
- Shortness of breath
Kidney and other symptoms include:
- Burning sensation when urinating
Nausea and vomiting Pale skin
- Swelling (edema) in any area of the body, especially in the legs
Exams and Tests
A physical examination may reveal signs of
Urinalysis results are usually abnormal, and show blood and protein in the urine. Abnormal red blood cells may be seen.
The following tests may also be done:
Anti-glomerular basement membrane test
Arterial blood gas
The main goal is to remove the harmful antibodies from the blood. A treatment called plasmapheresis removes whole blood from the body and replaces the plasma with fluid, protein, or donated plasma. Removing harmful antibodies may reduce inflammation in the kidneys and lungs.
Corticosteroid medications (such as prednisone) and other drugs that suppress or quiet the immune system may be used.
Controlling blood pressure is the most important way to delay kidney damage. You may get medicines to control high blood pressure, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs).
You may be told to limit salt and fluids to control swelling. A low to moderate protein diet may be recommended in some cases.
You should be closely watched for signs of kidney failure. If kidney failure becomes severe, you may need
If you permanently lose kidney function, you may need a kidney transplant. A transplant is not done until the level of harmful antibodies drops.
An early diagnosis is very important. The outlook is much worse if the kidneys are already severely damaged when treatment begins. Lung damage can range from mild to severe.
Many patients will need dialysis or a kidney transplant.
Chronic kidney disease End-stage kidney disease
- Lung failure
- Rapidly progressive glomerulonephritis
- Severe pulmonary hemorrhage (lung bleeding)
When to Contact a Medical Professional
Call for an appointment with your health care provider if you are producing less urine, or you have any other symptoms of Goodpasture syndrome.
Never sniff glue or siphon gasoline with your mouth, which expose the lungs to hydrocarbon solvents and can cause the disease.