Hairy cell leukemia (HCL) is an unusual cancer of the blood. It affects B cells, a type of white blood cell (lymphocyte).
Leukemic reticuloendotheliosis; HCL; Leukemia – hairy cell
Causes, incidence, and risk factors
HCL is caused by the abnormal growth of B cells. The cells look “hairy” under the microscope because they have fine projections coming from their surface.
HCL usually leads to low numbers of normal blood cells.
The cause of this disease is unknown. It affects men more often than women. The average age of diagnosis is 55.
- Easy bruising or bleeding
- Excessive sweating (especially at night)
- Feeling full after eating only a small amount
- Recurrent infections and fevers
- Pain or fullness in the upper left belly
Swollen lymph glands Weakness
- Weight loss
Signs and tests
During a physical exam, the doctor may be able to feel a
Blood tests and a
Treatment may not be needed for the early stages of this disease. Some patients may need an occasional blood transfusion.
If treatment is needed because of very low blood counts, a variety of chemotherapy drugs can be used. Drugs that may be used include cladribine, pentostatin, and rituximab.
In most cases, chemotherapy can relieve the symptoms for many years. (When the signs and symptoms go away, you are said to be in remission.) Interferon can relieve symptoms but is unlikely to lead to remission.
Removing the spleen may improve blood counts, but is unlikely to cure the disease. Antibiotics can be used to treat infections. People with low blood counts will receive growth factors and, possibly, transfusions.
Newer chemotherapy treatments have greatly improved the survival of patients with hairy cell leukemia. Most patients with hairy cell leukemia can expect to live 10 years or longer after diagnosis.
The low blood counts caused by hairy cell leukemia can lead to infections, fatigue, and excessive bleeding.
Calling your health care provider
Call your health care provider if you have significant bleeding. Also call if you have signs of infection, such as a persistent
There is no known way to prevent this disease.