Nephropathy is damage, disease, or other problems with the kidney. IgA nephropathy is a kidney disorder in which
It is also called Berger’s disease.
Nephropathy – IgA; Berger’s disease
IgA is a protein called an antibody that helps the body fight infections. IgA nephropathy (Berger’s disease) occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed and damaged.
IgA nephropathy (Berger’s disease) is a form of mesangial proliferative nephritis.
The disorder can appear suddenly (
Risk factors include:
- A personal or family history of IgA nephropathy or Henoch Schonlein
purpura, a form of vasculitisthat affects many parts of the body
- Caucasian or Asian ethnicity
IgA nephropathy can occur in people of all ages, but it most often affects males in their teens to late 30s.
There may be no symptoms for many years.
- Bloody urine that starts during or soon after a respiratory infection
- Repeated episodes of dark or bloody urine
- Swelling of the hands and feet
- Symptoms of
chronic kidney disease
Exams and Tests
IgA nephropathy usually is discovered when a person with no other symptoms of kidney problems has one or more episodes of dark or bloody urine.
There are no specific changes seen during a physical examination. Sometimes, the blood pressure may be high or there may be swelling of the body.
Blood urea nitrogen(BUN) blood test to measure kidney function
Creatinine blood testto measure kidney function
Kidney biopsyto confirm the diagnosis Urinalysis Urine immunoelectrophoresis
The goal of treatment is to relieve symptoms and prevent or delay
You may get medicines to control high blood pressure and swelling (
Corticosteroids, other drugs that suppress the immune system, and fish oil have also been used to treat this disorder.
Salt and fluids may be restricted to control swelling. A low to moderate
Some people will need to take medicines to lower their cholesterol.
Eventually, many patients must be treated for chronic kidney disease and may need dialysis.
For additional information and support, see the IgA Nephropathy Support Network website (
IgA nephropathy gets worse slowly. In many cases, it does not get worse at all. Your condition is more likely to get worse if you have:
High blood pressure
Large amounts of
protein in the urine
Increased BUN or creatinine levels
About 25% of adults with IgA nephropathy develop
Acute nephritic syndromeor nephrotic syndrome Chronic kidney failure End-stage kidney disease
When to Contact a Medical Professional
Call your health care provider if you have bloody urine or if you are producing less urine than usual.