Paget’s disease is a disorder that involves abnormal bone destruction and regrowth, which results in deformity.
Causes, incidence, and risk factors
The cause of Paget’s disease is unknown, although it might have to do with genes or a viral infection early in life.
The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand.
In people with Paget’s disease, there is an abnormal breakdown of bone tissue, followed by abnormal bone formation. The new bone is bigger, but weaker and filled with new blood vessels.
The disease may only be in one or two areas of the skeleton, or throughout the body. It often involves bones of the arms, collarbones, leg, pelvis, spine, and skull.
Most patients have no symptoms. Paget’s disease is often diagnosed when an x-ray is done for another reason.
If they do occur, symptoms may include:
Bone pain, joint pain or stiffness, and neck pain (the pain may be severe and present most of the time)
- Bowing of the legs and other visible deformities
- Enlarged head and skull deformities
Fracture Headache Hearing loss
- Reduced height
- Warm skin over the affected bone
Signs and tests
Tests that may indicate Paget’s disease include:
Bone scan Bone x-ray
- Elevated markers of bone breakdown (for instance, N-telopeptide)
serum alkaline phosphatase
This disease may also affect the results of the following tests:
ALP (alkaline phosphatase) isoenzyme Serum calcium
Patients who may not need treatment include those who:
- Only have abnormal blood tests
- Have no symptoms and no evidence of active disease
Patients with Paget’s disease who are commonly treated include patients who have:
- Certain bones, such as weight-bearing bones, involved, or bony changes that are getting worse quickly (treatment can reduce the risk of fractures)
- Pain or other symptoms
- Problems with the skull, to prevent hearing loss
Drug therapy helps prevent further bone breakdown. Currently, there are several classes of medications used to treat Paget’s disease. These include:
Bisphosphonates — These drugs are the first treatment, and they help increase bone density. They may be taken by mouth or given through a vein (intravenously) less often.
- Calcitonin — This hormone is involved in bone metabolism. It may be given as a nasal spray (Miacalcin), or as an injection under the skin (Calcimar or Mithracin)
Acetaminophen (Tylenol) or nonsteroidal anti-inflammatory medications (NSAIDs) may also be given for pain. Orthopedic surgery may be needed to correct a deformity in severe cases.
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Disease activity and symptoms can generally be controlled with current medications. A small percentage of patients may develop a cancer of the bone called
Calling your health care provider
Call for an appointment with your health care provider if you develop symptoms of Paget’s disease.