Post-streptococcal glomerulonephritis (GN) is a disorder of the kidneys that occurs after infection with certain strains of Streptococcus bacteria.
Glomerulonephritis – post-streptococcal; Post-infectious glomerulonephritis
Post-streptococcal GN is a form of
The strep bacterial infection causes the tiny blood vessels in the filtering units of the kidneys (glomeruli) to become inflamed. This makes the kidneys less able to filter the urine.
Post-streptococcal GN is uncommon today because infections that can lead to the disorder are commonly treated with antibiotics. The disorder may develop 1 – 2 weeks after an untreated throat infection, or 3 – 4 weeks after a skin infection.
It may occur in people of any age, but it most often occurs in children ages 6 – 10. Although skin and throat infections are common in children, post-streptococcal glomerulonephritis is a rare complication of these infections.
Risk factors include:
Streptococcal skin infections (such as
Decreased urine output
- Rust-colored urine
- Swelling (edema), general swelling, swelling of the abdomen, swelling of the face or eyes, swelling of the feet, ankles, hands
blood in the urine
Other symptoms that may occur with this disease:
Joint pain Joint stiffnessor swelling
Exams and Tests
A physical examination shows swelling (edema), especially in the face. Abnormal sounds may be heard when listening to the heart and lungs with a stethoscope (
Other tests that may be done include:
Anti-DNase B Kidney biopsy(this is usually not needed) Serum ASO(and streptolysin O)
Serum complement levels
There is no specific treatment for post-streptococcal glomerulonephritis. Treatment is focused on relieving symptoms.
Antibiotics, such as penicillin, should be used to destroy any streptococcal bacteria that remain in the body.
Blood pressure medications and diuretic medications may be needed to control swelling and high blood pressure.
Corticosteroids and other anti-inflammatory medications are generally not effective.
You may need to limit salt in the diet to control swelling and high blood pressure.
Post-streptococcal glomerulonephritis usually goes away by itself after several weeks to months.
In small number of adults, it may get worse and lead to chronic kidney failure. Sometimes it can progress to end-stage kidney disease, which requires dialysis and a kidney transplant.
Acute renal failure
- Chronic glomerulonephritis
- Chronic renal disease
Congestive heart failureor pulmonary edema End-stage renal disease Hyperkalemia
- High blood pressure (hypertension)
When to Contact a Medical Professional
Call your health care provider if:
You have symptoms of post-streptococcal GN
You have post-streptococcal GN, and you have decreased urine output or other new symptoms
Treating known streptococcal infections may prevent post-streptococcal GN.