Coordinated Health

Conditions

Definition

Apolipoprotein CII (apoCII) is a protein found in large fat particles absorbed from the gastrointestinal tract. It is also found in very low density lipoprotein (VLDL), which is made up of mostly triglycerides.

This article discusses the test used to check for apoCII in a sample of your blood.

Alternative Names

ApoCII; Apoprotein CII; ApoC2

How the test is performed

A blood sample is needed.

How to prepare for the test

You may be told not to eat or drink anything for 4 – 6 hours before the test.

How the test will feel

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed

ApoCII measurements can help to determine the specific type or cause of high blood lipids (hyperlipidemia).

Normal Values

The normal range is 3 – 5 mg/dL. However, apo CII is usually reported as present or absent.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What abnormal results mean

High levels of apoCII may be due to:

  • Angina pectoris
  • Familial lipoprotein lipase deficiency
  • Heart attack

Low apoCII levels are seen in persons with a rare condition called familial apoprotein CII deficiency. This causes chylomicronemia syndrome.

What the risks are

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

Special considerations

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown.

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