The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the
Creatinine is a breakdown product of creatine, which is an important part of muscle.
How the Test is Performed
This test requires both a
How to Prepare for the Test
Your health care provider may ask you to temporarily stop any medicines that may affect the test results. These include antibiotics and stomach acid medicines. Be sure to tell your provider about all the medicines you take.
Do not stop taking any medicine before talking to your doctor.
How the Test will Feel
The urine test involves only normal urination. There is no discomfort.
To draw blood, when the needle is inserted, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. These soon go away.
Why the Test is Performed
The creatinine clearance test is used to estimate
Creatinine is removed, or cleared, from the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood because less creatinine is released through the urine.
Clearance is often measured as milliliters/minute (ml/min). Normal values are:
- Male: 97 to 137 ml/min.
- Female: 88 to 128 ml/min.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
Abnormal results (lower than normal creatinine clearance) may indicate:
Kidney problems, such as
damage to the tubule cells Kidney failure
- Too little blood flow to the kidneys
Damage to the filtering units of the kidneys
- Loss of body fluids (dehydration)
- Bladder outlet obstruction
- Heart failure
Risks of the test involve the blood draw process.
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)