Familial combined hyperlipidemia is a disorder of high cholesterol and
Multiple lipoprotein-type hyperlipidemia
Causes, incidence, and risk factors
Familial combined hyperlipidemia is the most common genetic disorder of increased blood fats that causes early heart attacks. However, researchers have not yet identified the specific genes responsible.
Chest pain (angina) may occur. However, there may not be any physical symptoms.
Persons with this condition develop high cholesterol or triglyceride levels during the teenage years. The levels remain high throughout life. They have an increased risk of early
Signs and tests
Blood tests will be done to check your levels of cholesterol and triglycerides. Specific tests include:
LDL test (increased)
HDL test (decreased)
Apolipoprotein B100 test(increased)
Genetic testing is available for one type of familial combined hyperlipidemia.
The goal of treatment is to reduce the risk of
The first step is to change what you eat. Most of the time, this is tried for several months before your doctor recommends medicines, too. Diet changes include lowering the amount of fat in your diet so it is less than 30% of your total calories.
Here are some ways to eat less saturated fat:
- Eat less beef, chicken, pork, and lamb
- Substitute low-fat dairy products for full-fat ones
- Eliminate palm oil
You can reduce your the amount of cholesterol you eat by eliminating egg yolks and organ meats.
Counseling is often recommended to help people make changes to their eating habits. Weight loss and regular exercise may also help lower your cholesterol levels.
If lifestyle changes do not change your cholesterol levels, or you are at very high risk of developing atherosclerotic heart disease, your doctor may recommend medication. There are several types of drugs available to help lower blood cholesterol levels, and they work in different ways. Some are better at lowering LDL cholesterol, some are good at lowering triglycerides, while others help raise HDL cholesterol.
The most commonly used and effective drugs for treating high LDL cholesterol are called statins. The include lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), fluvastatin (Lescol), atorvastatin (Lipitor), rosuvastatin (Crestor), and pitivastatin (Livalo).
Other cholesterol-lowering medicines include:
- Bile acid-sequestering resins
- Fibrates (such as gemfibrozil and fenofibrate)
How well you do depends on how early the condition is diagnosed, when treatment is received, and whether you follow your treatment instructions. Without treatment, heart attack or stroke may cause early death.
Even with medicine, some people may continue to have high lipid levels that increase their risk of heart attack.
Early atherosclerotic heart disease
Calling your health care provider
Seek immediate medical care if you have chest pain or other warning signs of a heart attack.
Call for an appointment with your health care provider if you have a personal or family history of high cholesterol levels.
A low-cholesterol, low-saturated fat diet in high-risk individuals may help to control LDL levels.
If someone in your family has this condition, you may want to consider genetic screening for yourself or your children. Sometimes younger children may have mild
It is important to control other risk factors for early heart attacks, such as smoking, if you have this disease.