Interstitial nephritis is a kidney disorder in which the spaces between the kidney tubules become swollen (inflamed). This can cause problems with the way your kidneys work.
Tubulointerstitial nephritis; Nephritis – interstitial; Acute interstitial (allergic) nephritis
Interstitial nephritis may be temporary (
The acute form of interstitial nephritis is most often caused by side effects of certain drugs.
The following can cause interstitial nephritis:
Allergic reactionto a drug (acute interstitial allergic nephritis)
- Autoimmune disorders such as anti-tubular basement membrane disease, Kawasaki’s disease, Sjogren syndrome, systemic lupus erythematosus, or Wegener’s granulomatosis
Long-term use of medications such as acetaminophen (Tylenol), aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDS). This is called
Side effect of certain antibiotics (including penicillin, ampicillin, methicillin, sulfonamide medications, and others)
Side effect of other medications such as furosemide, thiazide diuretics, omeprazole, triamterene, and allopurinol
Too little potassium in your blood
Too much calcium or uric acid in your blood
Interstitial nephritis can cause mild to severe kidney problems, including
Symptoms of this condition may include:
Blood in the urine Fever
- Increased or
decreased urine output Mental status changes( drowsiness, confusion, coma) Nausea, vomiting Rash Swellingof the body, any area Weight gain(from retaining fluid)
Exams and Tests
The health care provider will perform a physical exam. This may reveal:
- Abnormal lung or heart sounds
- High blood pressure
- Fluid in the lungs (pulmonary edema)
Common tests include:
Arterial blood gases Blood chemistry BUNand blood creatininelevels Complete blood count Kidney biopsy
- Kidney ultrasound
Treatment depends on the cause of the problem. Avoiding medications that lead to this condition may relieve symptoms quickly.
Limiting salt and fluid in the diet can improve swelling and high blood pressure. Limiting
If dialysis is necessary, it usually is required for only a short time.
Corticosteroids or stronger anti-inflammatory medications such as cyclophosphamide can sometimes be helpful.
Most often, interstitial nephritis is a short-term disorder. In rare cases, it can cause permanent damage, including chronic kidney failure.
Acute interstitial nephritis may be more severe and more likely to lead to long-term or permanent
When to Contact a Medical Professional
Call your health care provider if you have symptoms of interstitial nephritis.
If you have interstitial nephritis, call your health care provider if you get new symptoms, especially if you are less alert or have a decrease in urine output.
In many cases, the disorder can’t be prevented. Avoiding or reducing your use of medications that can cause this condition can help reduce your risk.