Membranoproliferative glomerulonephritis is a kidney disorder that involves inflammation and changes to kidney cells. It may lead to kidney problems.
Membranoproliferative GN I; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Membranoproliferative glomerulonephritis; Lobular GN; Glomerulonephritis – membranoproliferative; MPGN type I; MPGN type II
Membranoproliferative GN is a form of glomerulonephritis caused by an abnormal
Damage to this membrane affects the kidney’s ability to create urine normally. It may allow blood and protein to leak into the urine. If enough protein leaks into the urine, fluid may leak out of the blood vessels into body tissues, leading to swelling (
There are two forms of membranoproliferative GN:
- Membranoproliferative GN I
- Membranoproliferative GN II
Most people with the disease have type I. Membranoproliferative GN II is much less common. It also tends to get worse faster than membranoproliferative GN I.
Many cases of membranoproliferative GN are due to causes such as:
Autoimmune diseases (
systemic lupus erythematosus, scleroderma, Sjogren syndrome, sarcoidosis)
Cancer (leukemia, lymphoma)
hepatitis B, hepatitis C, endocarditis, malaria)
The conditions mostly affect people ages 8 to 16.
Blood in the urine Changes in mental statussuch as decreased alertnessor decreased concentration Cloudy urine Dark urine(smoke, cola, or tea colored) Decrease in urine volume
- Foamy urine
Swellingof any part of the body
Exams and Tests
Your doctor or nurse will examine you. You may have swelling (usually in the legs), along with other signs of fluid overload, such as abnormal sounds when listening to the heart and lungs with a stethoscope.
Blood pressure is often high.
Membranoproliferative GN may be seen as:
Acute nephritic syndrome
The following tests help confirm the diagnosis:
BUNand creatinineblood test Blood complement C3 level Blood complement levels Urinalysis Urine protein
Treatment depends on the symptoms. The goals of treatment are to reduce symptoms, prevent complications, and slow the progression of the disorder.
You may need a change in diet. This may include limiting salt, fluids, or protein to help control high blood pressure, swelling, and the buildup of waste products in the blood.
Medicines that may be prescribed include:
Blood pressure medications
- Dipyridamole, with or without aspirin
Medications to suppress the immune system, such as cyclophosphamide
Treatment is more effective in children than in adults. Dialysis or
The disorder often slowly gets worse and eventually results in
Half of patients with this condition develop chronic kidney failure within 10 years. This is more likely in those who have higher levels of protein in their urine.
Acute nephritic syndrome Acute renal failure Chronic kidney disease End-stage kidney disease Nephrotic syndrome
When to Contact a Medical Professional
Call for an appointment with your health care provider if:
You have symptoms of this condition
Your symptoms get worse or do not go away
You develop new symptoms, including decreased urine output
Prevention is often not possible.