Takayasu arteritis is an inflammation of the aorta and
The cause of Takayasu arteritis is unknown. The disease occurs mainly in children and women younger than 40. It is more common in people from of Asian or African descent.
Takayasu arteritis appears to be an autoimmune condition, which means the body’s immune system mistakenly attacks healthy tissue. The condition may also involve other organ systems.
Arm weakness or pain with use
- Muscle or joint pain
- Skin rash
- Night sweats
- Vision changes
- Weight loss
Exams and Tests
- Decreased radial pulses (at the wrist)
- Difference in blood pressure between the two arms
- High blood pressure (
There may also be signs of inflammation (
Angiogram Complete blood count(CBC) C-reactive protein(CRP) Electrocardiogram(ECG) Erythrocyte sedimentation rate(ESR) Magnetic resonance angiography(MRA) Magnetic resonance imaging(MRI)
- Computed tomography (CT)
Ultrasound X-ray of the chest
Treatment of Takayasu arteritis is difficult. However, people who have the right treatment can see positive results. It is important to identify the condition early.
Most people are first treated with high doses of steroids. Immunosuppressive drugs, such as azathioprine, mycophenolate, methotrexate, or leflunomide are often added.
Biologic agents including TNF inhibitors such as infliximab are recommended for people who do not improve with the previous treatment.
In difficult cases, tocilizumab or rituximab may be helpful.
Surgery is reserved for complications caused by narrowed arteries.
This disease can be fatal without treatment. However, a combined treatment approach using medicines and surgery has lowered death rates. Adults have a better chance at survival than children.
- Blood clot
- Heart attack
- Heart failure
When to Contact a Medical Professional
Call your health care provider if you have symptoms of this condition. Weak pulse, chest pain, and breathing difficulty require immediate care.