Whipple’s disease is a rare condition that prevents the small intestines from properly absorbing nutrients. This is called
Causes, incidence, and risk factors
Whipple’s disease is caused by infection with a bacteria called Tropheryma whippelii. The disorder mainly affects middle-aged white men.
Whipple’s disease is extremely rare. Risk factors are unknown.
Symptoms usually start slowly. Joint paint is the most common initial symptom. After that, often several years later, symptoms of gastrointestinal (GI) infection develop. Other symptoms may include:
Abdominal pain Diarrhea
Gray to brown skin color Joint pain
in the ankles, knees, elbows, fingers, or other areas
- Memory loss
- Weight loss
Signs and tests
The doctor or nurse will perform a physical exam. This may show:
Enlarged lymph glands Heart murmur
- Swelling in body tissues (
Tests to diagnose Whipple’s disease may include:
- Complete blood count (
- Polymerase chain reaction (PCR) test to check for the bacteria that causes the disease
- Small bowel
- Upper GI
endoscopy(viewing the intestines with a flexible, lighted tube in a process called enteroscopy)
This disease may also change the results of the following tests:
Albuminlevels in the blood
Unabsorbed fat in the stools (
- Intestinal absorption of a type of sugar (
People with Whipple’s disease need to take long-term antibiotics to cure any infections of the brain and central nervous system. An antibiotic called ceftriaxone is given through a vein (IV). It is followed by another antibiotic (such as trimethoprim-sulfamethoxazole) taken by mouth for up to 1 year.
If symptoms come back during antibiotic use, the antibiotic treatment may be changed.
Your health care provider should closely follow your progress, because signs of the disease can return after you finish therapy. Those who have nutritional deficiencies from malabsorption will also need to take dietary supplements.
Without treatment, the condition is usually fatal. Treatment relieves symptoms and can cure the disease.
- Brain damage
- Heart valve damage (from
- Nutritional deficiencies
- Symptoms return (which may be because of drug resistance)
Calling your health care provider
Call your health care provider if you have persistent joint pain, abdominal pain, or diarrhea.
If you are being treated for Whipple’s disease, call your health care provider if:
Symptoms worsen or do not improve
New symptoms develop